Clinical neuropharmacology · 2012
Pregabalin resolves refractory aparathyroid paroxysmal kinesigenic choreoathetosis.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Baek William S
Аннотация
OBJECTIVE: The objective of this study was to determine the potential efficacy of pregabalin as treatment for aparathyroid paroxysmal kinesigenic choreoathetosis.
METHOD: This was a case report.
RESULTS: A 54-year-old white woman presented with a 20-year history of choreoathetoid and ballistic movements, which had developed as the result of parathyroidectomy. On examination, she demonstrated classic choreoathetoid movements with gait ataxia. Cognition was normal. Parathyroid hormone levels were near-absent with the rest of her workup being normal. Pregabalin 100 mg 3 times daily decreased her movements based on the Unified Huntington's Disease Rating Scale from 46 to 0.
CONCLUSIONS: It is unclear how pregabalin, which acts on the calcium channel α(2) δ-1 subunit, can help aparathyroid paroxysmal kinesigenic choreoathetosis. Further studies are required to see if pregabalin normalizes calcium metabolism in the basal ganglia.
METHOD: This was a case report.
RESULTS: A 54-year-old white woman presented with a 20-year history of choreoathetoid and ballistic movements, which had developed as the result of parathyroidectomy. On examination, she demonstrated classic choreoathetoid movements with gait ataxia. Cognition was normal. Parathyroid hormone levels were near-absent with the rest of her workup being normal. Pregabalin 100 mg 3 times daily decreased her movements based on the Unified Huntington's Disease Rating Scale from 46 to 0.
CONCLUSIONS: It is unclear how pregabalin, which acts on the calcium channel α(2) δ-1 subunit, can help aparathyroid paroxysmal kinesigenic choreoathetosis. Further studies are required to see if pregabalin normalizes calcium metabolism in the basal ganglia.