Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy (REIDAC).
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История · было → стало
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Sánchez-Gilo Araceli, Gómez de la Fuente Enrique, Giménez-Arnau Ana M, Silvestre-Salvador Juan Francisco, Mercader-García Pedro, Sanz-Sánchez Tatiana, Zaragoza-Ninet Violeta, Córdoba-Guijarro Susana, Miquel-Miquel Javier, González-Pérez Ricardo, Ruiz-Gonzalez Inmaculada, Serra-Baldrich Esther, Carrascosa-Carrillo José Manuel, Ortiz de Frutos Francisco Javier, Rodríguez-Serna Mercedes, Gatica-Ortega María Elena, Paredes-Suárez Carmen, Navarro-Triviño Francisco J, Chicharro Pablo, Pastor-Nieto María Antonia, Barasoain Marta Andreu, Pereyra-Rodríguez José-Juan, Melé-Ninot Gemma, Sánchez-Pedreño Guillén Paloma, Elosua-González Marta, Descalzo Miguel Ángel, García-Doval Ignacio, Barba-Martín Raquel, Borrego Leopoldo
Аннотация
OBJECTIVES: To characterise the clinical-allergological profile of patients with DE and to compare it with non-DE HE subtypes.
METHODS: A multicentre, retrospective, observational study was conducted using data from the Spanish Contact Dermatitis Registry (2019-2024).
RESULTS: Of 4378 patients with HE, 559 were diagnosed with DE. A longer median disease duration (24 vs. 14 months) and more frequent palmoplantar involvement (16% vs. 7%) were observed in DE compared with non-DE HE. At least one positive patch test was identified in 43% of DE versus 52% in non-DE HE. Although overall sensitisation patterns were largely comparable, DE showed lower sensitisation rates to 2-HEMA, carba mix and thiuram mix. Occupational factors were less frequently implicated in DE (9% vs. 29%) compared with non-DE HE.
CONCLUSIONS: Despite a high overall frequency of contact allergen sensitisation, the pattern of findings suggests that the dyshidrotic phenotype may follow a clinical course less dependent on external or occupational triggers, pointing towards a relatively greater contribution of endogenous factors compared with other HE subtypes.