American journal of Alzheimer's disease and other dementias · 2021
Clinical Markers May Identify Patients at Risk for Early Parkinson's Disease Dementia: A Prospective Study.
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Jurcau Anamaria, Nunkoo Vharoon Sharma
Аннотация
BACKGROUND: The study aims at identifying features predictive of early onset of dementia in Parkinson's disease (PD).
METHODS: 103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.
RESULTS: By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = -.621, p < 0.001) and insomnia (r = -.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017).
CONCLUSION: Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.
METHODS: 103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.
RESULTS: By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = -.621, p < 0.001) and insomnia (r = -.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017).
CONCLUSION: Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.