Biological psychiatry · 2025
Neural Tracking of Social Navigation in Autism Spectrum Disorder.
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Banker Sarah M, Schafer Matthew, Barkley Sarah, Trayvick Jadyn, Chen Alissa, Peters Arabella W, Thinakaran Abigaël A, Gu Xiaosi, Foss-Feig Jennifer H, Schiller Daniela
Аннотация
BACKGROUND: As we navigate changing social landscapes, maintaining maps of interpersonal dynamics can help guide our choices. Autism spectrum disorder (ASD) is associated with social challenges that may affect the accumulation or application of social information. However, little is known about social cognitive mapping in autistic adults.
METHODS: Herein, we investigated differences in social navigation among 122 adults with ASD, typical development (TD), and misophonia (MIS) (included as a clinical comparison group) using a social interaction task during functional magnetic resonance imaging.
RESULTS: Compared with other groups, adults with ASD behaved socially distant from task characters. Nevertheless, the groups displayed comparable neural tracking of social distances in regions previously identified in nonclinical samples, including the posterior cingulate cortex (PCC), as well as the parahippocampal place area, where tracking uniquely related to cross-diagnostic social avoidance symptoms. In contrast, the ASD group showed distinctive hypoactivity in the temporal pole (TP) during social decisions, associated with smaller real-world social networks and reduced insight into their external symptoms. Additionally, while the TD and MIS groups showed functional decoupling between the TP and PCC during social decisions, this was not detected in ASD.
CONCLUSIONS: Adults with ASD showed distinct behaviors and neural activity during deliberation in social interactions. However, brain systems supporting social mapping appear preserved across groups, consistent with previous findings, which have now been extended to a clinically diverse sample. These results highlight both shared and ASD-specific neural mechanisms of social navigation, thereby offering insight into potential neural differences in how social evidence guides choices in ASD.
METHODS: Herein, we investigated differences in social navigation among 122 adults with ASD, typical development (TD), and misophonia (MIS) (included as a clinical comparison group) using a social interaction task during functional magnetic resonance imaging.
RESULTS: Compared with other groups, adults with ASD behaved socially distant from task characters. Nevertheless, the groups displayed comparable neural tracking of social distances in regions previously identified in nonclinical samples, including the posterior cingulate cortex (PCC), as well as the parahippocampal place area, where tracking uniquely related to cross-diagnostic social avoidance symptoms. In contrast, the ASD group showed distinctive hypoactivity in the temporal pole (TP) during social decisions, associated with smaller real-world social networks and reduced insight into their external symptoms. Additionally, while the TD and MIS groups showed functional decoupling between the TP and PCC during social decisions, this was not detected in ASD.
CONCLUSIONS: Adults with ASD showed distinct behaviors and neural activity during deliberation in social interactions. However, brain systems supporting social mapping appear preserved across groups, consistent with previous findings, which have now been extended to a clinically diverse sample. These results highlight both shared and ASD-specific neural mechanisms of social navigation, thereby offering insight into potential neural differences in how social evidence guides choices in ASD.