Amyloid and tau pathologies cross-talk to promote Alzheimeŕs disease: novel mechanistic insights.

Aging-related declines in energy metabolism represent a key risk factor for the development of amyloid pathology, the earliest hallmark of Alzheimer's disease. Aging also contributes to the emergence of the second major hallmark, tau pathology, whose propagation is facilitated by pre-existing amyloid accumulation. The overlap of amyloid and tau pathologies ultimately leads to neurodegeneration and the onset of Alzheimer's disease-the most prevalent form of dementia. Recent findings underscore a bidirectional relationship between amyloid and tau pathologies, highlighting novel mechanistic insights into their interactions.