Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shi Liu, Westwood Sarah, Baird Alison L, Winchester Laura, Dobricic Valerija, Kilpert Fabian, Hong Shengjun, Franke Andre, Hye Abdul, Ashton Nicholas J, Morgan Angharad R, Bos Isabelle, Vos Stephanie J B, Buckley Noel J, Kate Mara Ten, Scheltens Philip, Vandenberghe Rik, Gabel Silvy, Meersmans Karen, Engelborghs Sebastiaan, De Roeck Ellen E, Sleegers Kristel, Frisoni Giovanni B, Blin Olivier, Richardson Jill C, Bordet Régis, Molinuevo José L, Rami Lorena, Wallin Anders, Kettunen Petronella, Tsolaki Magda, Verhey Frans, Lleó Alberto, Alcolea Daniel, Popp Julius, Peyratout Gwendoline, Martinez-Lage Pablo, Tainta Mikel, Johannsen Peter, Teunissen Charlotte E, Freund-Levi Yvonne, Frölich Lutz, Legido-Quigley Cristina, Barkhof Frederik, Blennow Kaj, Zetterberg Henrik, Baker Susan, Morgan B Paul, Streffer Johannes, Visser Pieter Jelle, Bertram Lars, Lovestone Simon, Nevado-Holgado Alejo J
Аннотация
METHODS: 4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid.
RESULTS: A panel of proteins (n = 44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve = 0.78) and the replication group (area under the curve = 0.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization.
DISCUSSION: The results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition.