Neuro-degenerative diseases · 2019
Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Grimmer Timo, Goldhardt Oliver, Yakushev Igor, Ortner Marion, Sorg Christian, Diehl-Schmid Janine, Förstl Hans, Kurz Alexander, Perneczky Robert, Miners Scott
Аннотация
BACKGROUND: Neprilysin (NEP) cleaves amyloid-β 1-42 (Aβ42) in the brain. Hence, we aimed to elucidate the effect of NEP on Aβ42 in cerebrospinal fluid (CSF) and on in vivo brain amyloid load using amyloid positron emission tomography (PET) with [11C]PiB (Pittsburgh compound B). In addition, associations with the biomarkers for neuronal injury, CSF-tau and FDG-PET, were investigated.
METHODS: Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer's disease patients.
RESULTS: CSF-NEP was significantly inversely associated with CSF-Aβ42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET.
CONCLUSIONS: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer's pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration.
METHODS: Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer's disease patients.
RESULTS: CSF-NEP was significantly inversely associated with CSF-Aβ42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET.
CONCLUSIONS: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer's pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration.
Предметные рубрики MeSH
AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsApolipoprotein E4BiomarkersBrainBrain ChemistryCarbon RadioisotopesFemaleFluorine RadioisotopesFluorodeoxyglucose F18HumansMaleMental Status and Dementia TestsMiddle AgedNeprilysinNeuroimagingPeptide FragmentsPositron-Emission TomographyRadiopharmaceuticalsThiazolestau Proteins