Chemico-biological interactions · 2023
Mechanism of testicular injury induced by Di-ethylhexyl phthalate and its protective agents.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Lin Yuxuan, Xu Wenqi, Yang Ling, Chen Zhengguo, Zhai Jianan, Zhu Qi, Guo Zhifang, Wang Ningning, Zhang Cong, Deng Haoyuan, Wang Shaopeng, Yang Guang
Аннотация
Di-ethylhexyl phthalate (DEHP) is used as an important plasticizer in a wide range of products such as paints, food packaging, medical devices and children's toys. In recent years, there has been increasing interest in the toxic effects of DEHP on the male reproductive organs, the testicles. Here, we reviewed the basic pathways of testicular damage caused by DEHP. The mechanism involves oxidative stress, ferroptosis, interfering with hypothalamic-pituitary-gonadal axis (HPGA) and testosterone level. We summarized the protective agents that have been shown to be effective in repairing this type of testicular damage in recent years. This provides a new perspective and direction for future research into the health effects and molecular mechanisms of DEHP.