American journal of otolaryngology · 2026
Fibrin glue enhances early hearing recovery in tympanoplasty: A randomised controlled trial.
СтатьяРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Rahmaty Benyamin, Asgari Sanam, Sayyadi Mohammad, Kouhi Ali, Golparavaran Saeed, Aalizade Ali, Ashtiani Mohammad Taghi Khorsandi, Aghazadeh Kayvan
Аннотация
OBJECTIVE: To compare the efficacy of fibrin glue versus Gelfoam in cartilage tympanoplasty, focusing on graft uptake rates and short-term hearing outcomes.
METHODS: In this double-blind, randomised clinical trial, forty-six patients with dry tympanic membrane perforations were randomly allocated to two groups: fibrin glue with cartilage graft (Group A) and Gelfoam with cartilage graft (Group B). A single surgeon carried out all surgeries. Graft integrity and air-bone gap (ABG) closure (≤15 dB) were evaluated three months post-surgery.
RESULTS: Graft uptake rates were 91.3% in the fibrin group and 82.6% in the Gelfoam group (p > 0.05). However, ABG closure ≤15 dB was achieved in 87% of the fibrin group compared to 60.9% of the Gelfoam group (p = 0.044), indicating a significant improvement in early hearing outcomes.
CONCLUSION: Fibrin glue tympanoplasty achieved comparable graft uptake rates to conventional Gelfoam tympanoplasty, while providing superior short-term hearing improvement. Both techniques demonstrated comparable graft integration, while fibrin glue was associated with superior early hearing recovery.
METHODS: In this double-blind, randomised clinical trial, forty-six patients with dry tympanic membrane perforations were randomly allocated to two groups: fibrin glue with cartilage graft (Group A) and Gelfoam with cartilage graft (Group B). A single surgeon carried out all surgeries. Graft integrity and air-bone gap (ABG) closure (≤15 dB) were evaluated three months post-surgery.
RESULTS: Graft uptake rates were 91.3% in the fibrin group and 82.6% in the Gelfoam group (p > 0.05). However, ABG closure ≤15 dB was achieved in 87% of the fibrin group compared to 60.9% of the Gelfoam group (p = 0.044), indicating a significant improvement in early hearing outcomes.
CONCLUSION: Fibrin glue tympanoplasty achieved comparable graft uptake rates to conventional Gelfoam tympanoplasty, while providing superior short-term hearing improvement. Both techniques demonstrated comparable graft integration, while fibrin glue was associated with superior early hearing recovery.