Clinical oral implants research · 2025
Osseointegration in the Absence of Primary Stability: An Experimental Preclinical Mandibular Minipig Overpreparation In Vivo Model.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Gill Thomas, Ooi Hansley, Tezulas Emre, Petrie Aviva, Rawlinson Simon, Roccuzzo Mario, Shahdad Shakeel
Аннотация
OBJECTIVES: The effect of osteotomy overpreparation, and thus lack of primary stability, on implant osseointegration and crestal bone volume maintenance was investigated by comparing placement of dental implants with either a standard osteotomy preparation (NP) or an overprepared osteotomy (OP) where the final osteotomy drill was larger in diameter than the implant placed.
METHODS: Bone-level implants (Ø3.3 mm diameter) were placed in the mandible of minipigs with two preparation techniques: an NP (Group 1) and an OP to a final osteotomy of 3.5 mm in diameter (Group 2) and submerged for 2 and 8 weeks. An Implant Stability Quotient (ISQ) was measured for each implant at placement. Implant survival, defined histologically as the absence of fibrous encapsulation and the presence of direct bone-to-implant contact, osseointegration and crestal bone formation were analysed histologically and histomorphometrically to compare the preparation techniques.
RESULTS: A 100% survival for both preparation types was observed. The mean ISQ at insertion for Groups 1 and 2 was 69.35 a.u. (95% CI: 68.02-70.68) and 11.95 a.u. (95% CI: 10.53-13.37) respectively (p < 0.001). At 2 and 8 weeks, there was no difference between the two groups for total bone-to-implant contact (tBIC) (p > 0.05). Group 2 demonstrated significantly higher mean first bone-to-implant contact (fBIC), coronal bone-to-implant contact (cBIC) and bone-area-to-total-area (BATA) at 2 and 8 weeks compared to Group 1 (p < 0.05).
CONCLUSION: Implants inserted into an overprepared osteotomy with no primary stability successfully osseointegrated. At 2 and 8 weeks, OP resulted in significantly more coronal bone apposition and maintenance of coronal bone volume as measured by fBIC, cBIC and BATA.
METHODS: Bone-level implants (Ø3.3 mm diameter) were placed in the mandible of minipigs with two preparation techniques: an NP (Group 1) and an OP to a final osteotomy of 3.5 mm in diameter (Group 2) and submerged for 2 and 8 weeks. An Implant Stability Quotient (ISQ) was measured for each implant at placement. Implant survival, defined histologically as the absence of fibrous encapsulation and the presence of direct bone-to-implant contact, osseointegration and crestal bone formation were analysed histologically and histomorphometrically to compare the preparation techniques.
RESULTS: A 100% survival for both preparation types was observed. The mean ISQ at insertion for Groups 1 and 2 was 69.35 a.u. (95% CI: 68.02-70.68) and 11.95 a.u. (95% CI: 10.53-13.37) respectively (p < 0.001). At 2 and 8 weeks, there was no difference between the two groups for total bone-to-implant contact (tBIC) (p > 0.05). Group 2 demonstrated significantly higher mean first bone-to-implant contact (fBIC), coronal bone-to-implant contact (cBIC) and bone-area-to-total-area (BATA) at 2 and 8 weeks compared to Group 1 (p < 0.05).
CONCLUSION: Implants inserted into an overprepared osteotomy with no primary stability successfully osseointegrated. At 2 and 8 weeks, OP resulted in significantly more coronal bone apposition and maintenance of coronal bone volume as measured by fBIC, cBIC and BATA.