Effects of electroconvulsive therapy on the use of anxiolytics and sleep medications: a propensity score-matched analysis.
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Tsuboi Takashi, Takaesu Yoshikazu, Hasegawa Naomi, Ochi Shinichiro, Fukumoto Kentaro, Ohi Kazutaka, Muraoka Hiroyuki, Okada Tsuyoshi, Kodaka Funitoshi, Igarashi Shun, Iida Hitoshi, Kashiwagi Hiroko, Hori Hikaru, Ichihashi Kayo, Ogasawara Kazuyoshi, Hashimoto Naoki, Iga Jun-Ichi, Nakamura Toshinori, Usami Masahide, Nagasawa Tatsuya, Kido Mikio, Komatsu Hiroshi, Yamagata Hirotaka, Atake Kiyokazu, Furihata Ryuji, Kikuchi Saya, Horai Tadasu, Takeshima Masahiro, Hirano Yoji, Makinodan Manabu, Matsumoto Junya, Miura Kenichiro, Hishimoto Akitoyo, Numata Shusuke, Yamada Hisashi, Yasui-Furukori Norio, Inada Ken, Watanabe Koichiro, Hashimoto Ryota
Аннотация
METHODS: This nationwide observational study analyzed data from 3483 MDD inpatients and 6663 SZ inpatients. Patients with MDD and SZ were classified into those who underwent ECT during hospitalization and those who did not. A propensity score-matching method was performed to adjust for preadmission characteristics and clinical information, which were expected bias between the two groups. Rates of anxiolytic and sleep medication use at discharge were compared in the matched sample.
RESULTS: 500 MDD patients were assigned to both groups. In the matched MDD sample, the rate of anxiolytic and sleep medication use at discharge was significantly lower in the ECT group than in the non-ECT group (64.9% vs. 75.8%, P = 1.7 × 10-4 ). In the ECT group, the rate of anxiolytic and sleep medication use at discharge was significantly lower than that prior to admission (64.9% vs. 73.2%, P = 1.2 × 10-14 ). 390 SZ patients were allocated. In the matched SZ sample, the ECT group was not significantly different from the non-ECT group in the rate of anxiolytics and sleep medications use at discharge (61.3% vs. 68.2%, P = 4.3 × 10-2 ). In the ECT group, the rate of anxiolytics and sleep medications use at discharge was significantly lower than that before admission (61.3% vs. 70.5%, P = 4.4 × 10-4 ), although this was not the primary outcome.
CONCLUSION: Reduction of anxiolytic and sleep medication use may be considered positively when ECT is indicated for treatment of MDD.