European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
The effectiveness and safety of combining platelet-rich plasma with cartilage tympanoplasty type 1 to treat tympanic membrane perforations: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
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Kang Yun Jin, Stybayeva Gulnaz, Hwang Se Hwan
Аннотация
PURPOSE: We evaluated the effectiveness of cartilage tympanoplasty type 1 combined with platelet-rich plasma (PRP) compared to cartilage tympanoplasty type 1 alone in dry tympanic membrane (TM) perforation due to chronic otitis media, demonstrating the safety and efficacy of PRP in tissue repair and regeneration.
METHODS: Data were retrieved from the literature up to April 2025. Outcomes of interest were success rate (complete closure of the TM postoperatively), postoperative air-conduction (AC) threshold, and changes in air-bone gap (ABG) and AC threshold (preoperatively to postoperatively). Pooled effects were calculated using standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs).
RESULTS: PRP-augmented cartilage tympanoplasty type 1 significantly improved ABG and AC compared to cartilage tympanoplasty type 1 alone (SMD 0.4517; 95% CI [0.1010; 0.8025], I2 = 0.0%) and AC (SMD 0.6193, 95% CI [0.2088; 1.0297]; I2 = 0.0%), and postoperative AC thresholds were significantly lower (SMD - 0.6194, 95% CI [- 0.9810; -0.2577]; I2 = 22.7%). The success rate of cartilage tympanoplasty type 1 with PRP significantly increased compared to cartilage tympanoplasty type 1 alone (OR 6.8721; 95% CI [3.2868; 14.3683], I2 = 0.0%) and combination therapy resulted in superior outcomes in all follow-up periods. PRP significantly reduced postoperative infection rates, but there was no significant difference in infection incidence between the two groups (OR 0.1843, 95% CI [0.0208; 1.6359]; I2 = 0.0%).
CONCLUSION: The autologous PRP application during cartilage tympanoplasty type 1 leads to higher success rates and greater hearing improvement, and also increases the success rate during all follow-up periods.
METHODS: Data were retrieved from the literature up to April 2025. Outcomes of interest were success rate (complete closure of the TM postoperatively), postoperative air-conduction (AC) threshold, and changes in air-bone gap (ABG) and AC threshold (preoperatively to postoperatively). Pooled effects were calculated using standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs).
RESULTS: PRP-augmented cartilage tympanoplasty type 1 significantly improved ABG and AC compared to cartilage tympanoplasty type 1 alone (SMD 0.4517; 95% CI [0.1010; 0.8025], I2 = 0.0%) and AC (SMD 0.6193, 95% CI [0.2088; 1.0297]; I2 = 0.0%), and postoperative AC thresholds were significantly lower (SMD - 0.6194, 95% CI [- 0.9810; -0.2577]; I2 = 22.7%). The success rate of cartilage tympanoplasty type 1 with PRP significantly increased compared to cartilage tympanoplasty type 1 alone (OR 6.8721; 95% CI [3.2868; 14.3683], I2 = 0.0%) and combination therapy resulted in superior outcomes in all follow-up periods. PRP significantly reduced postoperative infection rates, but there was no significant difference in infection incidence between the two groups (OR 0.1843, 95% CI [0.0208; 1.6359]; I2 = 0.0%).
CONCLUSION: The autologous PRP application during cartilage tympanoplasty type 1 leads to higher success rates and greater hearing improvement, and also increases the success rate during all follow-up periods.