Cancer discovery · 2022
Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Wu Lingxiang, Wu Wei, Zhang Junxia, Zhao Zheng, Li Liangyu, Zhu Mengyan, Wu Min, Wu Fan, Zhou Fengqi, Du Yuxin, Chai Rui-Chao, Zhang Wei, Qiu Xiaoguang, Liu Quanzhong, Wang Ziyu, Li Jie, Li Kening, Chen Apeng, Jiang Yinan, Xiao Xiangwei, Zou Han, Srivastava Rashmi, Zhang Tingting, Cai Yun, Liang Yuan, Huang Bin, Zhang Ruohan, Lin Fan, Hu Lang, Wang Xiuxing, Qian Xu, Lv Sali, Hu Baoli, Zheng Siyuan, Hu Zhibin, Shen Hongbing, You Yongping, Verhaak Roel G W, Jiang Tao, Wang Qianghu
Аннотация
UNLABELLED: Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight multifocal IDH wild-type primary GBMs and defined a natural evolution signature (NES) of the tumor. We show that the NES significantly associates with the activation of transcription factors that regulate brain development, including MYBL2 and FOSL2. Hypoxia is involved in inducing NES transition potentially via activation of the HIF1A-FOSL2 axis. High-NES tumor cells could recruit and polarize bone marrow-derived macrophages through activation of the FOSL2-ANXA1-FPR1/3 axis. These polarized macrophages can efficiently suppress T-cell activity and accelerate NES transition in tumor cells. Moreover, the polarized macrophages could upregulate CCL2 to induce tumor cell migration.
SIGNIFICANCE: GBM progression could be induced by hypoxia via the HIF1A-FOSL2 axis. Tumor-derived ANXA1 is associated with recruitment and polarization of bone marrow-derived macrophages to suppress the immunoenvironment. The polarized macrophages promote tumor cell NES transition and migration. This article is highlighted in the In This Issue feature, p. 2711.
SIGNIFICANCE: GBM progression could be induced by hypoxia via the HIF1A-FOSL2 axis. Tumor-derived ANXA1 is associated with recruitment and polarization of bone marrow-derived macrophages to suppress the immunoenvironment. The polarized macrophages promote tumor cell NES transition and migration. This article is highlighted in the In This Issue feature, p. 2711.