Investigation of factors related to treatment planning of x-ray SBRT and scanning carbon-ion radiation therapy for early-stage lung cancer patients.

This study aimed to compare the treatment plans of x-ray SBRT and scanning carbon ion radiation therapy (CIRT) for localized lung tumors, and to evaluate the dose dependence of tumor size tumor-to-heart distance. For phantom verification, we used a chest phantom with a spherical simulated tumor. Treatment plans for 3-dimensional conformal radiation therapy (3D-CRT), volumetric modulated arc therapy (VMAT), and CIRT were created. GTVs were created in sizes ranging from 0.5 to 5 cm in diameter, and the dependence of the lung dose on GTV diameter was evaluated for each treatment plan. For patient validation, 30 cases of localized lung tumors were analyzed. 3D-CRT, VMAT, and CIRT treatment plans were developed, and DVH parameters were evaluated for each GTV size and GTV-to-heart distance. In both phantom and patient validations, the OAR doses were the lowest for CIRT. The lung dose increased with increasing GTV diameter for all three treatment plans. CIRT had the smallest ratio of lung dose increase to GTV diameter increase among the three treatment plans. Heart dose in CIRT was independent of GTV size and GTV-to-heart distance Conclusions: The results of the present study suggested that the use of scanning CIRT can reduce the OAR dose while guaranteeing the tumor dose compared to x-ray SBRT. In addition, it was suggested that CIRT can treat patients with large GTV sizes while maintaining low lung and heart dose.