Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project.
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Bauckneht Matteo, Chincarini Andrea, Brendel Matthias, Rominger Axel, Beyer Leonie, Bruffaerts Rose, Vandenberghe Rik, Kramberger Milica G, Trost Maja, Garibotto Valentina, Nicastro Nicolas, Frisoni Giovanni B, Lemstra Afina W, van Berckel Bart N M, Pilotto Andrea, Padovani Alessandro, Ochoa-Figueroa Miguel A, Davidsson Anette, Camacho Valle, Peira Enrico, Arnaldi Dario, Pardini Matteo, Donegani Maria Isabella, Raffa Stefano, Miceli Alberto, Sambuceti Gianmario, Aarsland Dag, Nobili Flavio, Morbelli Silvia
Аннотация
INTRODUCTION: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern.
METHODS: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age).
RESULTS: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent).
DISCUSSION: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.
METHODS: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age).
RESULTS: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent).
DISCUSSION: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.