Stroke · 2006
Long-lasting regeneration after ischemia in the cerebral cortex.
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Leker Ronen R, Soldner Frank, Velasco Ivan, Gavin Denise K, Androutsellis-Theotokis Andreas, McKay Ronald D G
Аннотация
BACKGROUND AND PURPOSE: Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia.
METHODS: Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.
RESULTS: Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.
CONCLUSIONS: Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.
METHODS: Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.
RESULTS: Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.
CONCLUSIONS: Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.
Предметные рубрики MeSH
AnimalsBiomarkersBrain InfarctionBrain IschemiaBromodeoxyuridineCell ProliferationCerebral CortexDependovirusDisease Models, AnimalFibroblast Growth Factor 2Genetic TherapyGenetic VectorsGreen Fluorescent ProteinsInfarction, Middle Cerebral ArteryNerve RegenerationNeuronal PlasticityRatsRats, Inbred SHRRecovery of FunctionStem CellsTransfectionTreatment Outcome