Journal of affective disorders · 2025
Default mode network and reward network dysconnectivity among young individuals with major depressive disorder with and without systemic low-grade inflammation.
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Bai Ya-Mei, Cheng Li-Kai, Lin Wei-Chen, Hsu Ju-Wei, Chen Li-Fen, Tu Pei-Chi, Li Cheng-Ta, Tsai Shih-Jen, Chen Li-Chi, Su Tung-Ping, Chen Mu-Hong
Аннотация
BACKGROUND: Evidence indicates that up to 30 % of patients with major depressive disorder (MDD) exhibit low-grade inflammation (LGI). However, the effect of LGI on functional connectivity (FC) involving the default mode network (DMN) and reward network remains unclear among young patients with MDD.
METHODS: A total of 161 young people with MDD and 112 age-matched healthy individuals were included in this study. Among patients with MDD, 23 met the LGI criteria (C-reactive protein levels ≥3 mg/L). All participants underwent resting-state FC magnetic resonance imaging.
RESULTS: Seed-based connectivity analysis revealed that functional dysconnectivity in the DMN was unique to patients with MDD and LGI. They included decreased FC between the medial prefrontal cortex (mPFC) and bilateral lingual gyrus, decreased FC between the right lateral parietal cortex and both the right angular gyrus and right calcarine fissure, increased FC between the mPFC and the left cerebellum crus II, and increased FC between the left nucleus accumbens and both the right hippocampus and left anterior insula. Moreover, regardless of LGI status, patients with MDD exhibited increased FC within the DMN, confirming an increase in FC between the posterior cingulate cortex and the precuneus and between the left lateral parietal cortex and the right supramarginal gyrus.
DISCUSSION: LGI significantly affects both the DMN and reward network in patients with depression.
METHODS: A total of 161 young people with MDD and 112 age-matched healthy individuals were included in this study. Among patients with MDD, 23 met the LGI criteria (C-reactive protein levels ≥3 mg/L). All participants underwent resting-state FC magnetic resonance imaging.
RESULTS: Seed-based connectivity analysis revealed that functional dysconnectivity in the DMN was unique to patients with MDD and LGI. They included decreased FC between the medial prefrontal cortex (mPFC) and bilateral lingual gyrus, decreased FC between the right lateral parietal cortex and both the right angular gyrus and right calcarine fissure, increased FC between the mPFC and the left cerebellum crus II, and increased FC between the left nucleus accumbens and both the right hippocampus and left anterior insula. Moreover, regardless of LGI status, patients with MDD exhibited increased FC within the DMN, confirming an increase in FC between the posterior cingulate cortex and the precuneus and between the left lateral parietal cortex and the right supramarginal gyrus.
DISCUSSION: LGI significantly affects both the DMN and reward network in patients with depression.