Медицинская библиотека · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2007

Low levels of second-line drug resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Rwanda.

Umubyeyi A, Rigouts L, Shamputa I C, Dediste A, Struelens M, Portaels F

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Аннотация

BACKGROUND

Multidrug-resistant tuberculosis (MDR-TB) has become a therapeutic problem in many parts of the world, necessitating the inclusion of second-line anti-tuberculosis drugs in specific treatment regimens.

METHODS

We studied the susceptibility of 69 MDR Mycobacterium tuberculosis isolates from Rwanda to second-line drugs by the BACTEC 460 method.

RESULTS

The results showed that 62 (89.9%) were resistant to rifabutin while a low rate (4.3%) of resistance was registered for ofloxacin; there was one case (1.4%) of resistance each for para-aminosalicylic acid, kanamycin, ethionamide, and clarithromycin.

CONCLUSIONS

This information is important for devising an appropriate treatment regimen for MDR-TB patients in order to stop the spread of MDR strains and contain the acquisition of additional drug resistance in Rwanda.

Для цитирования: Umubyeyi A, Rigouts L, Shamputa I C, Dediste A, Struelens M, Portaels F. Low levels of second-line drug resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Rwanda.. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2007. DOI: 10.1016/j.ijid.2007.05.003.

Предметные рубрики MeSH

Adult Aminosalicylic Acids Anti-Bacterial Agents Antitubercular Agents Clarithromycin Drug Resistance, Multiple, Bacterial Ethionamide Female Humans Kanamycin Male Microbial Sensitivity Tests Mycobacterium tuberculosis Ofloxacin Rwanda Tuberculosis, Multidrug-Resistant

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