Interplay between physical activity, tau pathophysiology, and cognition.

Physical activity (PA) has emerged as a modifiable protective lifestyle factor for Alzheimer's disease (AD). In a recent study by Kim and colleagues, higher levels of PA were associated with reduced phosphorylated tau (ptau) 217 concentrations even after accounting for β-amyloid (Aβ) brain uptake, suggesting a link with tau pathophysiology; this link also mediated better general cognition.