[Changes of prostaglandin E2 levels in periapical exudates after root canal treatment].

OBJECTIVE

The aim of this study was to examine the levels of prostaglandin E2 in periapical exudates before and after root canal treatment.

METHODS

Periapical exudates specimens were quantitatively sampled from root canals of 25 teeth at consecutive treatment visits, and the concentration of prostaglandin E2 in each sample was determined using a commercial kit.

RESULTS

The mean prostaglandin E2 levels significantly decreased after the endodontic therapy. Significant correlations between the levels of prostaglandin E2 and the clinical features of periapical periodontitis were also found in this study.

CONCLUSION

The results suggest that the level of prostaglandin E2 in periapical exudates reflects the state of periapical periodontitis.