[The role of alfa-2-beta-adrenoreceptor in development of ventricular conduction disturbance].

BACKGROUND

The purpose of this study was to investigate association between the genetic polymorphism I/D of gene α2β-adrenoreceptor (ADRA2B) and hereditary disorders of ventricular conduction.

PATIENTS AND

METHODS

In this study, 102 people with complete left bundle branch block (45.71 ± 1.852 years)--46 females and 56 males, and 86 people with complete right bundle branch block (34.59 ± 1.86 years)--41 females and 45 males. The study was approved by Ethic Committee of the KrasSMU. All participants were included in the study after written informed consent form. Cardiological examination included clinical examination, electrocardiography, echocardiography, Holter monitoring, stress-test, koronaroangiografy and radionuclide method of a myocardium and molecular and genetic researches.

RESULTS

Statistically, significant prevalence of a homozygous genotype of DD on rare allele gene ADRA2B in both groups in comparison with group of control is established. The reliable dominance of the homozygous rare genotypes (D allele) of gene ADRA2B were detected in all groups.

CONCLUSION

Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.