Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy.

The newly emerging nanotheranostic strategies including photodynamic therapy (PDT), photothermal therapy (PTT) and sonodynamic therapy (SDT) have exhibited their unbeatable advantages in treatment and prognosis of glioma tumors as compared to conventional ones like chemotherapy, radiotherapy and surgery. Meanwhile, the components of glioma microenvironment including blood brain barrier (BBB), oxidative stress, hypoxia and angiogenesis, play essential roles in glioma initiation, progression, invasion, recurrence and drug resistance. More importantly, the nanoparticles can modulate the glioma environments to increase targeting capability, monitor the glioma growth, and enhance therapy outcomes. In this review, we will introduce the basic components of glioma microenvironment, the role that glioma microenvironment played on tumor development and progression, and the key perspectives associated with glioma microenvironment-based multifunctional nanoplatform design. In particular, recent advances in glioma microenvironment-response nanoparticles for phototherapy (PTT and PDT) and sonotherapy will be discussed in detail. Finally, the challenges related to the clinical transition for nanomedicine-based glioma theranostics will be addressed.