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DOI 10.21873/anticanres.13148

Медицинская библиотека · Anticancer research · 2019

High miR-3687 Expression Affects Migratory and Invasive Ability of Oesophageal Carcinoma.

Hagio Kotaro, Furuya Shinji, Nakamura Jiro, Maruyama Suguru, Shiraishi Kensuke, Shimizu Hiroki, Akaike Hidenori, Hosomura Naohiro, Kawaguchi Yoshihiko, Amemiya Hidetake, Kawaida Hiromichi, Sudo Makoto, Inoue Shingo, Kono Hiroshi, Ichikawa Daisuke

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Аннотация

BACKGROUND/AIM: Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the prognostic impact of miR-3687 in ESCC and determine the role of miR-3687 in ESCC motility.

MATERIALS AND

METHODS

miR-3687 expression in human ESCC cell lines and in primary tumour samples obtained from patients with ESCC who underwent esophagectomy were analyzed via real-time polymerase chain reaction (PCR). Knockdown and over-expression experiments were conducted with miR-3687 siRNA and miRNA mimic, and the effect on cell proliferation, migration, and invasion was analyzed.

RESULTS

A total of 92 samples were analyzed. High miR-3687 expression was correlated with poor prognosis. miR-3687 upregulation promoted cell migration and invasion.

CONCLUSION

miR-3687 expression negatively impacts the prognosis of patients with ESCC.

Для цитирования: Hagio Kotaro, Furuya Shinji, Nakamura Jiro, Maruyama Suguru, Shiraishi Kensuke, Shimizu Hiroki, Akaike Hidenori, Hosomura Naohiro, Kawaguchi Yoshihiko, Amemiya Hidetake, Kawaida Hiromichi, Sudo Makoto, Inoue Shingo, Kono Hiroshi, Ichikawa Daisuke. High miR-3687 Expression Affects Migratory and Invasive Ability of Oesophageal Carcinoma.. Anticancer research. 2019. DOI: 10.21873/anticanres.13148.

Предметные рубрики MeSH

AgedCarcinoma, Squamous CellCell DifferentiationCell Line, TumorCell MovementCell ProliferationEsophageal NeoplasmsEsophagectomyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedNeoplasm InvasivenessPolymerase Chain ReactionPrognosisRNA, Small Interfering
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