Exploring the complex dimensions of Alzheimer's disease: The promising role of circular RNAs and their potential contributions.

Circular RNAs (circRNAs) are multifunctional molecules that regulate gene expression at transcriptional and post-transcriptional levels. They are generated through the back-splicing of mRNA precursors and exhibit tissue-specific expression patterns. CircRNAs highly conserved among various species, exhibit significant abundance and dynamic expression within the nervous system, especially at synaptic sites. Research has shown varied distributions of circRNAs across different organs, including the brain, heart, liver, and lungs, with pronounced enrichment in the nervous system. Neurological disorders lead to alterations in gene expression, transcript profiles, and modifications of non-coding RNAs, including circRNAs. Alzheimer's disease is marked by the accumulation of amyloid-beta (Aβ) plaques and the presence of phosphorylated tau (P-tau) neurofibrillary tangles, both of which are key histological features that contribute to the pathophysiology of the disease. Notably, circRNAs cross the blood-brain barrier (BBB), presenting promising avenues for therapeutic interventions in neurological conditions like Alzheimer's disease (AD) due to their stability and the specificity of their expression in various tissues, circular RNAs are increasingly recognized as promising candidates for therapeutic intervention.