Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition.

BACKGROUND

Parkinson's disease (PD) is a chronic neurological disorder that affects millions of people worldwide. A common motor symptom associated with PD is gait impairment, leading to reduced step count and mobility.

METHODS

Monitoring and analyzing step count data can provide valuable insights into the progression of the disease and the effectiveness of various treatments. In our study, the generalized additive model (GAM) was used to identify statistically significant variables for step counts. Additionally, a web application was developed as an interactive visualization tool.

RESULTS

The GAM model shows that the following variables are statistically significant for daily step counts: sex (p = 0.03), handedness (p = 0.015), PD status of father (p = 0.056), COVID-19 status (Yes vs. No, p = 0.008), cohort (PD vs. Healthy, p < 0.0001), the cubic regression spline with three basis functions of age by cohorts (p < 0.0001), and the random effect of individual age trajectories (p = 0.0001).

CONCLUSIONS

Based on the PPMI data, we find that sex, handedness, PD status of father, COVID-19 status, cohort, and the smoothing functions of age are all statistically significant for step counts. Additionally, a web application tailored specifically for step count analysis in PD patients was developed. This tool provides a user-friendly interface for patients, caregivers, and healthcare professionals to track and analyze step count data, facilitating personalized treatment plans and enhancing the management of PD.