Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013
Outcomes of colorectal cancer arising in solid organ transplant recipients.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Merchea Amit, Abdelsattar Zaid M, Taner Timucin, Dean Patrick G, Colibaseanu Dorin T, Larson David W, Dozois Eric J
Аннотация
INTRODUCTION: The incidence of colorectal cancer posttransplantation is unclear. Limited reports exist and have conflicting conclusions. We aimed to review the clinical features and oncologic outcomes of colorectal cancer in transplant recipients at our institution.
METHODS: A retrospective review of all patients diagnosed with colorectal cancer after solid organ transplantation between 2000 and 2011 was conducted. Clinical features and outcomes were reviewed.
RESULTS: Twenty of 3,946 patients were identified. The most common single organ transplanted was the kidney (n = 8). Six patients had multiorgan transplantation. Median age of diagnosis of cancer was 64.3 years, and median time from transplant to diagnosis of cancer was 8.7 years. Ten patients were symptomatic at presentation. Cancer was identified on routine colonoscopy in seven patients. Tumors were most commonly found in the right colon (n = 14, 70%). Six patients had stage IV disease at presentation. Short-term morbidity was identified in 11 patients. Postoperative mortality occurred in one patient. Median follow-up was 2.47 years. Overall survival at 5 years was 69%, and disease-free survival was 68 %. Distant recurrence was seen in 3 (15%) patients.
CONCLUSION: Colorectal cancer in these patients is rare, and surgery can be done safely. Vigilant screening must be maintained in this patient population.
METHODS: A retrospective review of all patients diagnosed with colorectal cancer after solid organ transplantation between 2000 and 2011 was conducted. Clinical features and outcomes were reviewed.
RESULTS: Twenty of 3,946 patients were identified. The most common single organ transplanted was the kidney (n = 8). Six patients had multiorgan transplantation. Median age of diagnosis of cancer was 64.3 years, and median time from transplant to diagnosis of cancer was 8.7 years. Ten patients were symptomatic at presentation. Cancer was identified on routine colonoscopy in seven patients. Tumors were most commonly found in the right colon (n = 14, 70%). Six patients had stage IV disease at presentation. Short-term morbidity was identified in 11 patients. Postoperative mortality occurred in one patient. Median follow-up was 2.47 years. Overall survival at 5 years was 69%, and disease-free survival was 68 %. Distant recurrence was seen in 3 (15%) patients.
CONCLUSION: Colorectal cancer in these patients is rare, and surgery can be done safely. Vigilant screening must be maintained in this patient population.
Предметные рубрики MeSH
AdenocarcinomaAgedAged, 80 and overAnastomotic LeakColectomyColon, AscendingColon, TransverseColonoscopyColorectal NeoplasmsColostomyDisease-Free SurvivalHumansIleostomyIleusLength of StayMiddle AgedNeoplasm MetastasisNeoplasm StagingOrgan TransplantationProctocolectomy, RestorativeRetrospective StudiesSurgical Wound InfectionSurvival RateTime Factors