European journal of clinical nutrition · 2021
Vitamin D status and obesity in children from Chile.
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Pérez-Bravo Francisco, Duarte Lissette, Arredondo-Olguín Miguel, Iñiguez Germán, Castillo-Valenzuela Oscar
Аннотация
BACKGROUND: Vitamin D [25(OH)D] is essential for normal bone development and maintenance. Furthermore, its deficiency has been associated with obesity, cardiovascular diseases, insulin resistance, autoimmune diseases, and certain cancers.
OBJECTIVE: To determine the incidence of serum 25(OH)D deficiency (<20 ng/ml) among apparently healthy Chilean children (4-14 years old) from three Chilean geographic areas during May-September 2018.
MATERIALS AND METHODS: Serum 25(OH)D levels were measured by a competitive protein-binding ELISA assay in 1134 children, and correlations between serum 25(OH)D levels, BMI, and geographic area were calculated. Individuals were grouped according to their serum 25-hydroxyvitamin D levels (ng/ml): severe deficiency: <5; moderate deficiency: 5-10.9; mild deficiency: 11-20.9; insufficiency: 21-29.9 and sufficiency: 30-100.
RESULTS: We found 80.4% of children had serum 25(OH)D deficiency, with 1.7% severe, 24.6% moderate, and 54.1% mild. In the three cities, the percentage of serum 25(OH)D deficit was increased when comparing overweight or obesity with a healthy weight. Additionally, an interaction effect was observed between geographic area, nutritional status, and serum 25(OH)D levels using the factorial ANOVA test (p = 0.038). In Antofagasta, there were more overweight children and also a higher percentage of children with VitD deficiency (<30 ng/ml) compared to Santiago or Concepción.
CONCLUSION: This study revealed a high prevalence of serum 25(OH)D deficiency in children between 4 and 14 years old in Chile (80.4%) during May-September 2018. Obese and overweight children had the highest prevalence of serum 25(OH)D deficiency.
OBJECTIVE: To determine the incidence of serum 25(OH)D deficiency (<20 ng/ml) among apparently healthy Chilean children (4-14 years old) from three Chilean geographic areas during May-September 2018.
MATERIALS AND METHODS: Serum 25(OH)D levels were measured by a competitive protein-binding ELISA assay in 1134 children, and correlations between serum 25(OH)D levels, BMI, and geographic area were calculated. Individuals were grouped according to their serum 25-hydroxyvitamin D levels (ng/ml): severe deficiency: <5; moderate deficiency: 5-10.9; mild deficiency: 11-20.9; insufficiency: 21-29.9 and sufficiency: 30-100.
RESULTS: We found 80.4% of children had serum 25(OH)D deficiency, with 1.7% severe, 24.6% moderate, and 54.1% mild. In the three cities, the percentage of serum 25(OH)D deficit was increased when comparing overweight or obesity with a healthy weight. Additionally, an interaction effect was observed between geographic area, nutritional status, and serum 25(OH)D levels using the factorial ANOVA test (p = 0.038). In Antofagasta, there were more overweight children and also a higher percentage of children with VitD deficiency (<30 ng/ml) compared to Santiago or Concepción.
CONCLUSION: This study revealed a high prevalence of serum 25(OH)D deficiency in children between 4 and 14 years old in Chile (80.4%) during May-September 2018. Obese and overweight children had the highest prevalence of serum 25(OH)D deficiency.