Neuroimmunomodulation · 2008
Neuropathy of gastrointestinal Chagas' disease: immune response to myelin antigens.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Oliveira Elaine C, Fujisawa Márcia M, Hallal Longo Dannie E M, Farias Alessandro S, Contin Moraes Juliana, Guariento Maria Elena, de Almeida Eros Antônio, Saad Mario José A, Langone Francesco, Toyama Marcos H, Andreollo Nelson A, Santos Leonilda M B
Аннотация
Most reports of autoimmune response during infection with the parasite Trypanosoma cruzi have dealt with the cardiomyopathic form of Chagas' disease, but little is known about the mechanisms of tissue damage involved in the gastrointestinal form, which was studied here. Chronically infected patients with a severe gastrointestinal form of Chagas' disease present increased antibody production and proliferative responses to peripheral myelin components, such as myelin basic protein (MBP), which is homologous to the P1 protein fraction of peripheral myelin. T lymphocytes preferentially recognize a region on the MBP molecule (1-30), which suggests that the MBP is a potential target on the peripheral nerve for autoimmune reactions in patients with gastrointestinal lesions resulting from Chagas' disease.
Предметные рубрики MeSH
AdultAnimalsAutoantibodiesAutoantigensAutoimmunityBrainChagas DiseaseEnteric Nervous SystemFemaleGastrointestinal DiseasesGastrointestinal TractHumansLymphocyte ActivationMaleMiddle AgedMyelin Basic ProteinMyelin ProteinsMyelin SheathNeuronsPeripheral NervesPolyradiculoneuropathyT-LymphocytesTrypanosoma cruzi