[Clinical efficacy of sodium tanshinone IIA sulfonate in treatment of advanced schistosomiasis].

OBJECTIVE

To evaluate the clinical efficacy of sodium tanshinone IIA sulfonate (STS) in the treatment of advanced schistosomiasis.

METHODS

Fifty cases with advanced schistosomiasis admitted to the Touzao Township Hospital of Dongtai City during the period from November 2012 to November 2013 were treated with STS for 10 days, and the internal diameter of the portal vein, levels of ALT, AST, gamma-GT, PIIIP, CIV, HA and LN were measured and compared before and after the administration of STS.

RESULTS

The mean levels of all serological parameters except HA were within the normal range before STS treatment, while the highest positive rate was detected in gamma-GT (26.0%) and HA (54.0%). Following the STS treatment, the mean levels of all parameters and the positive rates reduced, with the greatest reduction observed in gamma-GT (36.7%) and HA (37.8%); however, the mean HA level was still higher than the normal range. The mean internal diameter of the portal vein reduced from (10.5 +/- 1.7) mm before the STS treatment to (9.8 +/- 1.3) mm after the STS administration, with a significant diffrtence (P < 0.05).

CONCLUSION

STS appears effective in the treatment of advanced schistosomiasis.