The rationale for targeting nectin-4 in pancreatic cancer.

Nectin-4 is an immunoglobulinlike cell adhesion molecule that contributes to tumor aggressiveness and immune evasion in pancreatic ductal adenocarcinoma (PDAC). Its high and selective expression on pancreatic cancer cells, together with the clinical efficacy of nectin-4-targeted antibody-drug conjugates in other solid tumors, establishes nectin-4 as a compelling therapeutic target in PDAC.