Acta paediatrica (Oslo, Norway : 1992) · 2005
Tight junctions, leaky intestines, and pediatric diseases.
СтатьяПоддержка NIH: внешняя программаПоддержка службы здравоохранения СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Liu Z, Li N, Neu J
Аннотация
BACKGROUND: Tight junctions (TJs) represent the major barrier within the paracellular pathway between intestinal epithelial cells. Disruption of TJs leads to intestinal hyperpermeability (the so-called "leaky gut") and is implicated in the pathogenesis of several acute and chronic pediatric disease entities that are likely to have their origin during infancy.
AIM: This review provides an overview of evidence for the role of TJ breakdown in diseases such as systemic inflammatory response syndrome (SIRS), inflammatory bowel disease, type 1 diabetes, allergies, asthma, and autism.
CONCLUSION: A better basic understanding of this structure might lead to prevention or treatment of these diseases using nutritional or other means.
AIM: This review provides an overview of evidence for the role of TJ breakdown in diseases such as systemic inflammatory response syndrome (SIRS), inflammatory bowel disease, type 1 diabetes, allergies, asthma, and autism.
CONCLUSION: A better basic understanding of this structure might lead to prevention or treatment of these diseases using nutritional or other means.