Brain research. Gene expression patterns · 2002
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
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Chen Zhoutao, Ge Bing, Hudson Thomas J, Rozen Rima
Аннотация
Methylenetetrahydrofolate reductase (MTHFR) deficiency is the most common genetic cause of hyperhomocysteinemia, which is associated with increased risk for cardiovascular disease, stroke and possibly other neurological disorders. Microarray analysis of brain RNA from day 14 Mthfr(-/-) mice revealed several genes with altered expression. Expression changes in inositol 1,4,5-triphosphate receptor, type 1 (Itpr1), proteolipid protein (Plp), neurogenic differentiation factor 1 (Neurod1), S100 calcium binding protein A8 (S100a8), and methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (Mthfd2) were confirmed by RT-PCR. We propose that neuronal damage by hyperhomocysteinemia may involve disruption of intracellular calcium.
Предметные рубрики MeSH
ActinsAnimalsBasic Helix-Loop-Helix ProteinsBrainCalciumCalcium ChannelsCalgranulin AExpressed Sequence TagsHeterozygoteHyperhomocysteinemiaInositol 1,4,5-Trisphosphate ReceptorsMethenyltetrahydrofolate CyclohydrolaseMethylationMethylenetetrahydrofolate Dehydrogenase (NADP)Methylenetetrahydrofolate Reductase (NADPH2)MiceMice, Inbred BALB CMyelin Proteolipid ProteinNerve Tissue ProteinsNeuronsOligonucleotide Array Sequence AnalysisRNAReceptors, Cytoplasmic and NuclearReceptors, N-Methyl-D-AspartateReverse Transcriptase Polymerase Chain ReactionTime FactorsTranscription Factors