Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
Establishing a hereditary angioedema prevalence for the United States using a large administrative claims database.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Castaldo Anthony J, Wells Karen E, Khalid Subhan, Rashidi Emaan, Selva Christine N, Corcoran Deborah, Christiansen Sandra C, Riedl Marc A, Zuraw Bruce L, Loyo-Berrios Nilsa
Аннотация
BACKGROUND: Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder. No US prevalence for all types of HAE has been estimated. Approval of 8 effective HAE therapies in the United States significantly expanded treated patient numbers and data collected in claims databases.
OBJECTIVE: To provide the first US prevalence estimate of HAE (all types) using claims-based insurance data.
METHODS: This retrospective study estimated the US prevalence of HAE using IQVIA's PharMetrics Plus MedTech claims database. Patients with 24 months of continuous database enrollment were divided into the following 3 cohorts: 2018, 2019, and 2020. Owing to the absence of International Classification of Diseases, Ninth Revision, Clinical Modification or International Classification of Diseases, 10th Revision, Clinical Modification diagnostic codes specific to HAE, we developed a proxy algorithm using International Classification of Diseases, 10th Revision, Clinical Modification codes for "angioneurotic edema" or "defects in the complement system" with more than or equal to 1 pharmacy claim for an HAE-indicated medication. An expert panel reviewed anonymized patient-level aggregate claims data to determine HAE status. A sensitivity analysis generated adjustment factors to address underrepresentation of Medicare patients in PharMetrics Plus MedTech database.
RESULTS: For 2018, 2019, and 2020, the claims-based algorithm yielded overall annual unadjusted HAE prevalence estimates per 100,000 and number of people diagnosed with HAE of 2.67, 9559; 2.61, 9341; and 2.43, 8694, respectively. The corresponding estimates based on expert physician analysis were 2.13, 7602; 2.03, 7275; and 1.84, 6595, respectively.
CONCLUSION: Our study provides the first claims-based comprehensive estimate of the US prevalence for all types of HAE across age groups, sexes, and geographic regions. Our calculations (which exceed the frequently cited 2:100,000 prevalence for HAE with C1 inhibitor deficiency) afford a real-world projected prevalence encompassing all types of HAE.
OBJECTIVE: To provide the first US prevalence estimate of HAE (all types) using claims-based insurance data.
METHODS: This retrospective study estimated the US prevalence of HAE using IQVIA's PharMetrics Plus MedTech claims database. Patients with 24 months of continuous database enrollment were divided into the following 3 cohorts: 2018, 2019, and 2020. Owing to the absence of International Classification of Diseases, Ninth Revision, Clinical Modification or International Classification of Diseases, 10th Revision, Clinical Modification diagnostic codes specific to HAE, we developed a proxy algorithm using International Classification of Diseases, 10th Revision, Clinical Modification codes for "angioneurotic edema" or "defects in the complement system" with more than or equal to 1 pharmacy claim for an HAE-indicated medication. An expert panel reviewed anonymized patient-level aggregate claims data to determine HAE status. A sensitivity analysis generated adjustment factors to address underrepresentation of Medicare patients in PharMetrics Plus MedTech database.
RESULTS: For 2018, 2019, and 2020, the claims-based algorithm yielded overall annual unadjusted HAE prevalence estimates per 100,000 and number of people diagnosed with HAE of 2.67, 9559; 2.61, 9341; and 2.43, 8694, respectively. The corresponding estimates based on expert physician analysis were 2.13, 7602; 2.03, 7275; and 1.84, 6595, respectively.
CONCLUSION: Our study provides the first claims-based comprehensive estimate of the US prevalence for all types of HAE across age groups, sexes, and geographic regions. Our calculations (which exceed the frequently cited 2:100,000 prevalence for HAE with C1 inhibitor deficiency) afford a real-world projected prevalence encompassing all types of HAE.