Current eye research · 2026
Normative Database of Retinal Nerve Fiber Layer Thickness in a Caucasian Pediatric Population.
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Polách Ondřej, Koubek Michal, Timkovič Juraj, Studnička Jan, Březík Michal, Polách Jan, Němčanský Jan
Аннотация
PURPOSE: Here, we aimed to obtain normative data for the retinal nerve fiber layer thickness in the peripapillary area (p-RNFL) using the spectral domain optical coherence tomography (SD-OCT) in healthy Caucasian children using the OCT Spectralis instrument.
METHODS: Caucasian patients of our hospital 5-15 years with spherical equivalent refraction of ±2 diopters, physiological ocular findings, delivered at gestational age ≥38 weeks, whose legal guardians volunteered with their participation in this cross-sectional study and signed informed consent were included. Exclusion criteria were a personal history of toxoplasmosis and other diseases that could potentially affect p-RNFL thickness. Results of 3.5 mm circular p-RNFL scans with automatic calculation of the retinal nerve fiber layer thickness were prospectively collected. Both eyes were measured in each participant and values for the global diameter (G) and average thickness in six sectors (NS, N, NI, TI, T, TS) were determined and statistically evaluated.
RESULTS: 154 patients were included, with a mean age of 11.03 years. We have acquired data for p-RNFL in healthy Caucasian children aged 5-15 years and used them to create a normative database for improving the quality of the interpretation of the p-RNFL results in children. No significant differences between the left and right eyes in the same individuals were detected. However, a negative association between age and p-RNFL thickness, in particular in the NI sector, was revealed.
CONCLUSIONS: We have created a high-quality normative database that will allow us to accurately interpret the results of p-RNFL measurements in the Caucasian pediatric population.
METHODS: Caucasian patients of our hospital 5-15 years with spherical equivalent refraction of ±2 diopters, physiological ocular findings, delivered at gestational age ≥38 weeks, whose legal guardians volunteered with their participation in this cross-sectional study and signed informed consent were included. Exclusion criteria were a personal history of toxoplasmosis and other diseases that could potentially affect p-RNFL thickness. Results of 3.5 mm circular p-RNFL scans with automatic calculation of the retinal nerve fiber layer thickness were prospectively collected. Both eyes were measured in each participant and values for the global diameter (G) and average thickness in six sectors (NS, N, NI, TI, T, TS) were determined and statistically evaluated.
RESULTS: 154 patients were included, with a mean age of 11.03 years. We have acquired data for p-RNFL in healthy Caucasian children aged 5-15 years and used them to create a normative database for improving the quality of the interpretation of the p-RNFL results in children. No significant differences between the left and right eyes in the same individuals were detected. However, a negative association between age and p-RNFL thickness, in particular in the NI sector, was revealed.
CONCLUSIONS: We have created a high-quality normative database that will allow us to accurately interpret the results of p-RNFL measurements in the Caucasian pediatric population.