Oltipraz treatment in experimental schistosomiasis mansoni: IV. Histopathological changes in the intestines of infected mice induced by high dose oral therapy.

Marked improvement of the pathological lesions in the small intestines of mice experimentally infected with the Egyptian strain of S. mansoni was detected after oltipraz therapy. The drug was given in a single oral dose of 500 mg per kg body weight. The improvement of the intestinal lesions was apparent after 20, 30 and 60 days from treatment in comparison to the infected untreated controls. These findings were the basis of the present study, which still need investigations of the histopathological changes in livers of infected mice before and after oltipraz therapy.