Dopaminergic neurons entering the brain under the immunological cover of darkness.

The ability to transplant immunologically foreign cells into an animal without immune suppression would be transformative. Pavan et al. show that human pluripotent stem cell-derived dopaminergic neuron progenitors engineered to express eight immune-evasive proteins can engraft in humanized mice and a rat model of Parkinson's disease without recourse to immune suppression.1.