Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2026
Clinical characteristics and quality of life measures in children with glaucoma-suspect or glaucoma diagnoses in chronic, noninfectious uveitis.
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Miraldi Utz Virginia, Cassedy Amy, Aundhia Minal, Duell Alexandra, Quinlan-Waters Megan, Kaufman Adam H, Angeles-Han Sheila
Аннотация
BACKGROUND: The impact of glaucoma-suspect or glaucoma diagnoses on quality of life (QOL) outcomes in children with noninfectious uveitis (NIU) has not been well characterized. This study evaluated the impact of glaucoma-related diagnoses on vision-related QOL (VRQOL) and vision-related functioning (VRF) using the Effects of Youngsters' Eyesight on QOL (EYE-Q), overall QOL (Pediatric QOL Inventory: PedsQL), and anxiety and depression (Revised Children's Anxiety and Depression: RCAD).
METHODS: Children with chronic, NIU were categorized as no glaucoma (Gla-) and glaucoma-suspect or glaucoma (Gla+) for QOL analysis. Demographic and clinical data were collected. Patients and parents/proxies completed the EYE-Q, PedsQL, and RCADS. Statistical analyses were performed, with significance defined at P <0.05.
RESULTS: Seventy-six children (mean age, 10.7 ± 4.6 years; 71% female) were included, 36 (47%) with glaucoma-related diagnoses (Gla+). Most had bilateral (82%), anterior (91%) NIU and were associated with juvenile idiopathic arthritis (JIA) (67%). Children with JIA were less likely to develop Gla+. Affected eyes with glaucoma had more complications at NIU diagnosis (P = 0.003), including synechiae (P <0.001) and cataracts (P < 0.001), compared with the Gla- group. While Gla+ children had lower QOL scores than Gla- children, these differences were not statistically significant. However, parents of Gla+ children reported poorer VRF (P = 0.017), lower total EYE-Q scores (P = 0.013), and higher RCADS scores (P = 0.041), which persisted over time.
CONCLUSIONS: Non-JIA uveitis and eyes with complications at uveitis presentation are more likely to develop glaucoma-related diagnoses. Parents/proxies of children with Gla+ reported lower QOL scores in both eye-specific and psychosocial functioning, highlighting the need for behavioral health interventions.
METHODS: Children with chronic, NIU were categorized as no glaucoma (Gla-) and glaucoma-suspect or glaucoma (Gla+) for QOL analysis. Demographic and clinical data were collected. Patients and parents/proxies completed the EYE-Q, PedsQL, and RCADS. Statistical analyses were performed, with significance defined at P <0.05.
RESULTS: Seventy-six children (mean age, 10.7 ± 4.6 years; 71% female) were included, 36 (47%) with glaucoma-related diagnoses (Gla+). Most had bilateral (82%), anterior (91%) NIU and were associated with juvenile idiopathic arthritis (JIA) (67%). Children with JIA were less likely to develop Gla+. Affected eyes with glaucoma had more complications at NIU diagnosis (P = 0.003), including synechiae (P <0.001) and cataracts (P < 0.001), compared with the Gla- group. While Gla+ children had lower QOL scores than Gla- children, these differences were not statistically significant. However, parents of Gla+ children reported poorer VRF (P = 0.017), lower total EYE-Q scores (P = 0.013), and higher RCADS scores (P = 0.041), which persisted over time.
CONCLUSIONS: Non-JIA uveitis and eyes with complications at uveitis presentation are more likely to develop glaucoma-related diagnoses. Parents/proxies of children with Gla+ reported lower QOL scores in both eye-specific and psychosocial functioning, highlighting the need for behavioral health interventions.