Anais brasileiros de dermatologia · 2017
Chromoblastomycosis: tissue modifications during itraconazole treatment.
СтатьяНазвание и аннотация: Перевод в очереди
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Purim Kátia Sheylla Malta, Peretti Murilo Calvo, Fillus José, Olandoski Marcia
Аннотация
BACKGROUND:: Histological and mycological changes during itraconazole use have not been totally established in chromoblastomycosis.
OBJECTIVES:: To evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment.
METHODS:: A histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Patients were classified into two groups: plaque or tumor lesions, and underwent periodic evaluations every four months during three years. Hematoxylin-eosin stain was used to analyze epidermal modifications, inflammatory infiltrate and fibrosis, and Fontana-Masson stain for parasite evaluation.
RESULTS:: Fontana-Masson stain was superior to hematoxylin-eosin stain in fungal count in the epidermis (mean difference=0.14; p<0.05). The most distinct mycosis tissue responses were registered in the dermis. Epidermal thinning, granulomatous infiltrate decrease or disappearance, fibrosis increase and quantitative/morphological changes occurred during treatment.
STUDY LIMITATIONS:: Patients could not be located to have their current skin condition examined.
CONCLUSION:: Parasitic and tissue changes verified in this study can reflect the parasite-host dynamics under itraconazole action.
OBJECTIVES:: To evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment.
METHODS:: A histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Patients were classified into two groups: plaque or tumor lesions, and underwent periodic evaluations every four months during three years. Hematoxylin-eosin stain was used to analyze epidermal modifications, inflammatory infiltrate and fibrosis, and Fontana-Masson stain for parasite evaluation.
RESULTS:: Fontana-Masson stain was superior to hematoxylin-eosin stain in fungal count in the epidermis (mean difference=0.14; p<0.05). The most distinct mycosis tissue responses were registered in the dermis. Epidermal thinning, granulomatous infiltrate decrease or disappearance, fibrosis increase and quantitative/morphological changes occurred during treatment.
STUDY LIMITATIONS:: Patients could not be located to have their current skin condition examined.
CONCLUSION:: Parasitic and tissue changes verified in this study can reflect the parasite-host dynamics under itraconazole action.