Health bulletin · 1999
Early-onset dementia in Lothian, Scotland: an analysis of clinical features and patterns of decline.
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Woodburn K J, Johnstone E C
Аннотация
OBJECTIVE: To clinically characterise and diagnostically classify a sample of patients with early-onset dementia and determine the disabilities and nature of decline of each group, during a one year follow up.
DESIGN: The Lothian Postgraduate Case Register was used to identify a cohort of 126 live patients of various aetiologies with dementia diagnosed before the age of 65. Each had two assessments approximately one year apart. Demographic; behavioural and psychopathological; neurocognitive; neurological and genetic data were collected and compared.
SETTING: Patients were either in long term care or at home.
SUBJECTS: Of 126 cases (53 male, 73 female, mean age at referral 58 years), 114 met the diagnostic criteria for Diagnostic and Statistical Manual Third Edition dementia; 60 Alzheimer's type Dementia; 13 Multi-infarct Dementia; 14 Alcohol related Dementia; with 25 in a mixed group overlapping these categories; and two in 'other' dementia types. By the second assessment, 18 patients had died and two refused reassessment.
RESULTS: Levels of morbidity were high. The Alcohol group had a distinct profile and in general the dementia appeared less severe with minimal deterioration.
CONCLUSIONS: This study investigates and compares early onset dementia of various types and attempts to provide clear information on their outlook.
DESIGN: The Lothian Postgraduate Case Register was used to identify a cohort of 126 live patients of various aetiologies with dementia diagnosed before the age of 65. Each had two assessments approximately one year apart. Demographic; behavioural and psychopathological; neurocognitive; neurological and genetic data were collected and compared.
SETTING: Patients were either in long term care or at home.
SUBJECTS: Of 126 cases (53 male, 73 female, mean age at referral 58 years), 114 met the diagnostic criteria for Diagnostic and Statistical Manual Third Edition dementia; 60 Alzheimer's type Dementia; 13 Multi-infarct Dementia; 14 Alcohol related Dementia; with 25 in a mixed group overlapping these categories; and two in 'other' dementia types. By the second assessment, 18 patients had died and two refused reassessment.
RESULTS: Levels of morbidity were high. The Alcohol group had a distinct profile and in general the dementia appeared less severe with minimal deterioration.
CONCLUSIONS: This study investigates and compares early onset dementia of various types and attempts to provide clear information on their outlook.