The Pediatric Choroidal and Ciliary Body Melanoma Study: A Survey by the European Ophthalmic Oncology Group.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Al-Jamal Rana'a T, Cassoux Nathalie, Desjardins Laurence, Damato Bertil, Konstantinidis Lazaros, Coupland Sarah E, Heimann Heinrich, Petrovic Aleksandra, Zografos Leonidas, Schalenbourg Ann, Velazquez-Martin Juan P, Krema Hatem, Bogdali Anna, Markiewicz Anna, Romanowska-Dixon Bozena, Metz Claudia H D, Biewald Eva, Bornfeld Norbert, Kiratli Hayyam, Bronkhorst Inge H G, Jager Martine J, Marinkovic Marina, Fili Maria, Seregard Stefan, Frenkel Shahar, Pe'er Jacob, Salvi Sachin M, Rennie Ian G, Rospond-Kubiak Iwona, Kociecki Jaroslaw, Kiilgaard Jens Folke, Heegaard Steffen, Cohen Victoria M L, Sagoo Mandeep S, Amiryan Anush, Saakyan Svetlana, Eide Nils, Krohn Jørgen, Midena Edoardo, Parrozzani Raffaele, Grange Jean-Daniel, Kilic Emine, Blasi Maria Antonietta, Saornil Maria Antonia, Kivelä Tero T
Аннотация
DESIGN: Retrospective, multicenter observational study.
PARTICIPANTS: Two hundred ninety-nine patients from 24 ocular oncology centers, of whom 114 were children (median age, 15.1 years; range, 2.7-17.9 years) and 185 were young adults.
METHODS: Data were entered through a secure website and were reviewed centrally. Survival was analyzed using Kaplan-Meier analysis and Cox proportional hazards regression.
MAIN OUTCOME MEASURES: Proportion of females, tumor-node-metastasis (TNM) stage, cell type, and melanoma-related mortality.
RESULTS: Cumulative frequency of having CCBM diagnosed increased steadily by 0.8% per year of age between 5 and 10 years of age and, after a 6-year transition period, by 8.8% per year from age 17 years onward. Of children and young adults, 57% and 63% were female, respectively, which exceeded the expected 51% among young adults. Cell type, known for 35% of tumors, and TNM stage (I in 22% and 21%, II in 49% and 52%, III in 30% and 28%, respectively) were comparable for children and young adults. Melanoma-related survival was 97% and 90% at 5 years and 92% and 80% at 10 years for children compared with young adults, respectively (P = 0.013). Males tended to have a more favorable survival than females among children (100% vs. 85% at 10 years; P = 0.058). Increasing TNM stage was associated with poorer survival (stages I, II, and III: 100% vs. 86% vs. 76%, respectively; P = 0.0011). By multivariate analysis, being a young adult (adjusted hazard rate [HR], 2.57), a higher TNM stage (HR, 2.88 and 8.38 for stages II and III, respectively), and female gender (HR, 2.38) independently predicted less favorable survival. Ciliary body involvement and cell type were not associated with survival.
CONCLUSIONS: This study confirms that children with CCBM have a more favorable survival than young adults 18 to 25 years of age, adjusting for TNM stage and gender. The association between gender and survival varies between age groups.