Journal of pediatric surgery · 2015
Granular cell tumors and congenital granular cell epulis in children: Similar entities.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Alemayehu Hanna, Polites Stephanie F, Kats Alexander, Ishitani Michael B, Moir Christopher R, Iqbal Corey W
Аннотация
BACKGROUND/PURPOSE: Granular cell tumor (GCT) is an unusual lesion thought to originate from Schwann cells. Congenital granular cell epulis (CGCE) is a rare fibroma-like lesion arising from the alveolar ridge in newborns. These entities have been described as distinct entities.
METHODS: A retrospective review was performed of children with a histopathologic diagnosis of GCT or CGCE from 1991-2014. Data were recorded and analyzed. All values reported as the mean±standard deviation.
RESULTS: GCT or CGCE was identified in 41 patients with a mean age of 7.8±6.1years. Thirty-one patients had GCT, and 10 had CGCE. All patients underwent excisional biopsy, except 1 who underwent incisional biopsy only. Fifteen patients had positive margins after excision (12 GCT and 3 CGCE). Only 1 had a local recurrence, and this same patient had multifocal GCT. Only 1 patient had an invasive lesion without recurrence after wide local excision. All patients survived, with a median follow-up of 42.5months (0.2-204.2months).
CONCLUSION: In children, both GCT and CGCE exhibit benign behavior, and complete excision does not appear to be mandatory, as recurrence or invasive disease is rare. When invasive features are present, wide local excision should be undertaken.
METHODS: A retrospective review was performed of children with a histopathologic diagnosis of GCT or CGCE from 1991-2014. Data were recorded and analyzed. All values reported as the mean±standard deviation.
RESULTS: GCT or CGCE was identified in 41 patients with a mean age of 7.8±6.1years. Thirty-one patients had GCT, and 10 had CGCE. All patients underwent excisional biopsy, except 1 who underwent incisional biopsy only. Fifteen patients had positive margins after excision (12 GCT and 3 CGCE). Only 1 had a local recurrence, and this same patient had multifocal GCT. Only 1 patient had an invasive lesion without recurrence after wide local excision. All patients survived, with a median follow-up of 42.5months (0.2-204.2months).
CONCLUSION: In children, both GCT and CGCE exhibit benign behavior, and complete excision does not appear to be mandatory, as recurrence or invasive disease is rare. When invasive features are present, wide local excision should be undertaken.