World journal of gastroenterology · 2011
Is hyperhomocysteinemia relevant in patients with celiac disease?
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Casella Giovanni, Bassotti Gabrio, Villanacci Vincenzo, Di Bella Camillo, Pagni Fabio, Corti Gian Luigi, Sabatino Giuseppe, Piatti Mara, Baldini Vittorio
Аннотация
AIM: To investigate whether this might be related to the presence of hyperhomocysteinemia.
METHODS: From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years).
RESULTS: Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).
CONCLUSION: The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.
METHODS: From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years).
RESULTS: Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).
CONCLUSION: The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.