Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study.
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Menne Jan, Nitschke Martin, Stingele Robert, Abu-Tair Mariam, Beneke Jan, Bramstedt Jörn, Bremer Jan P, Brunkhorst Reinhard, Busch Veit, Dengler Reinhard, Deuschl Günther, Fellermann Klaus, Fickenscher Helmut, Gerigk Christoph, Goettsche Alexander, Greeve Jobst, Hafer Carsten, Hagenmüller Friedrich, Haller Hermann, Herget-Rosenthal Stefan, Hertenstein Bernd, Hofmann Christina, Lang Melanie, Kielstein Jan T, Klostermeier Ulrich C, Knobloch Johannes, Kuehbacher Markus, Kunzendorf Ulrich, Lehnert Hendrik, Manns Michael P, Menne Tobias F, Meyer Tobias N, Michael Claus, Münte Thomas, Neumann-Grutzeck Christine, Nuernberger Jens, Pavenstaedt Hermann, Ramazan Leyla, Renders Lutz, Repenthin Jonas, Ries Wolfgang, Rohr Axel, Rump Lars Christian, Samuelsson Ola, Sayk Friedhelm, Schmidt Bernhard M W, Schnatter Sabine, Schöcklmann Harald, Schreiber Stefan, von Seydewitz Cay U, Steinhoff Jürgen, Stracke Sylvia, Suerbaum Sebastian, van de Loo Andreas, Vischedyk Martin, Weissenborn Karin, Wellhöner Peter, Wiesner Monika, Zeissig Sebastian, Büning Jürgen, Schiffer Mario, Kuehbacher Tanja, EHEC-HUS consortium
Аннотация
DESIGN: Multicentre retrospective case-control study.
SETTING: 23 hospitals in northern Germany.
PARTICIPANTS: 298 adults with enterohaemorrhagic E coli induced haemolytic uraemic syndrome.
MAIN OUTCOME MEASURES: Dialysis, seizures, mechanical ventilation, abdominal surgery owing to perforation of the bowel or bowel necrosis, and death.
RESULTS: 160 of the 298 patients (54%) temporarily required dialysis, with only three needing treatment long term. 37 patients (12%) had seizures, 54 (18%) required mechanical ventilation, and 12 (4%) died. No clear benefit was found from use of plasmapheresis or plasmapheresis with glucocorticoids. 67 of the patients were treated with eculizumab, a monoclonal antibody directed against the complement cascade. No short term benefit was detected that could be attributed to this treatment. 52 patients in one centre that used a strategy of aggressive treatment with combined antibiotics had fewer seizures (2% v 15%, P = 0.03), fewer deaths (0% v 5%, p = 0.029), required no abdominal surgery, and excreted E coli for a shorter duration.
CONCLUSIONS: Enterohaemorrhagic E coli induced haemolytic uraemic syndrome is a severe self limiting acute condition. Our findings question the benefit of eculizumab and of plasmapheresis with or without glucocorticoids. Patients with established haemolytic uraemic syndrome seemed to benefit from antibiotic treatment and this should be investigated in a controlled trial.