Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes.
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Silva Lilian de Souza D'Albuquerque, de Queiroz Natércia Neves Marques, de Melo Franciane Trindade Cunha, Abrahão Neto João Felício, Janaú Luísa Corrêa, de Souza Neto Norberto Jorge Kzan, de Lemos Manuela Nascimento, de Oliveira Maria Clara Neres Iunes, de Alcântara Angélica Leite, de Moraes Lorena Vilhena, da Silva Wanderson Maia, de Souza Ícaro José Araújo, Said Nivin Mazen, de Lemos Gabriela Nascimento, Felício Karem Miléo, Dos Santos Márcia Costa, Motta Ana Regina Bastos, Dos Reis Melissa de Sá Oliveira, Lobato Isabel Jane Campos, de Figueiredo Priscila Boaventura Barbosa, de Souza Ana Carolina Contente Braga, Piani Pedro Paulo Freire, Felício João Soares
Аннотация
METHODS: We performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels <30 ng/ml received 10,000 IU/day; the ones with VD levels between 30-60 ng/ml were given 4,000 IU/day for 12 weeks.
RESULTS: There was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p <0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p <0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p <0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p < 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p <0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p<0.01; r= -0.5, p<0.05, respectively).
CONCLUSION: Our pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose.
CLINICAL TRIAL REGISTRATION: http://www.isrctn.com/ISRCTN32601947, identifier ISRCTN32601947.