Toxicological consequences of yellowjacket wasp and its larvae entomophagy in Himalayan region of Nepal; case report and review of literature.

Entomophagy, or insect consumption, is a common traditional practice in Asia, Africa, and South America including Nepal. Despite its longstanding cultural presence, there is limited literature on the toxicological effects of ingesting wasp larvae. This case report describes seven individuals who experienced toxicity after consuming pan-fried yellowjacket wasp larvae in August 2023. Symptoms included seizures, nausea, dizziness, blurred vision, and cardiovascular instability. The cases varied in severity, with some patients exhibiting profound hypotension and neurological symptoms. The symptoms suggest possible neurotoxic effects of venom components in wasp larvae, though some studies indicate larvae may lack venom glands. The slow progression and severity of symptoms highlight the need for further investigation into the toxicological profile of wasp larvae. Future research should focus on identifying specific venom components of yellowjackets, examining cooking impacts on toxicity, and exploring venom variations across wasp species to improve treatment approaches and safety protocols.