Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2026
Retinal microvascular alterations detected by optical coherence tomography angiography in patients with inflammatory bowel disease.
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Bilican Gülden, Akdağ İhsan, Özdemir Hüseyin Baran, Noor Nurulamin M, Haas Stephan L, Petrousis Grigorios, Xintara Maria, Kirman Derya, Acehan Fatih, Aksak Arif, Yılmaz Yusufcan, Soykan İrfan, Kalkan Çağdaş
Аннотация
BACKGROUND: Inflammatory bowel disease (IBD) is increasingly recognised as a systemic inflammatory disorder, yet subclinical microvascular alterations beyond the gastrointestinal tract remain poorly characterised.
AIMS: To evaluate retinal microvascular parameters measured by optical coherence tomography angiography (OCTA) in patients with IBD compared with healthy controls.
METHODS: Retinal microvascular parameters were evaluated by OCTA. Vessel density in the superficial and deep capillary plexus, foveal avascular zone metrics, and FD300 were analysed in patients with IBD and healthy controls.
RESULTS: A total of 114 participants were included (65 IBD, 49 controls). DCP vessel density was significantly reduced in patients with IBD across whole, hemispheric and perifoveal regions (all p < 0.001). SCP vessel density changes were more modest and were mainly observed in UC compared with controls (all p ≤ 0.030). FD300 was modestly reduced in IBD (p = 0.033). A modest negative correlation was observed between Crohn's Disease Activity Index and DCP whole vessel density (ρ = -0.335, p = 0.046).
CONCLUSION: Patients with IBD exhibit subclinical retinal microvascular alterations, most pronounced in the deep capillary plexus, that can be detected by OCTA, a non-invasive retinal imaging modality.
AIMS: To evaluate retinal microvascular parameters measured by optical coherence tomography angiography (OCTA) in patients with IBD compared with healthy controls.
METHODS: Retinal microvascular parameters were evaluated by OCTA. Vessel density in the superficial and deep capillary plexus, foveal avascular zone metrics, and FD300 were analysed in patients with IBD and healthy controls.
RESULTS: A total of 114 participants were included (65 IBD, 49 controls). DCP vessel density was significantly reduced in patients with IBD across whole, hemispheric and perifoveal regions (all p < 0.001). SCP vessel density changes were more modest and were mainly observed in UC compared with controls (all p ≤ 0.030). FD300 was modestly reduced in IBD (p = 0.033). A modest negative correlation was observed between Crohn's Disease Activity Index and DCP whole vessel density (ρ = -0.335, p = 0.046).
CONCLUSION: Patients with IBD exhibit subclinical retinal microvascular alterations, most pronounced in the deep capillary plexus, that can be detected by OCTA, a non-invasive retinal imaging modality.