Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2014
Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Tamura Katsutoshi, Harada Yasuji, Kunimi Maki, Takemitsu Hiroshi, Hara Yasushi, Nakamura Tatsuo, Tagawa Masahiro
Аннотация
OBJECTIVES: In dogs with deep analgesia caused by acute spinal cord injury from thoracolumbar disk herniation, autologous bone marrow mononuclear cell transplant may improve recovery. The purpose of the present study was to evaluate autologous bone marrow mononuclear cell transplant in a dog that had paraplegia and deep analgesia caused by chronic spinal cord injury.
MATERIALS AND METHODS: Autologous bone marrow mononuclear cell transplant was performed in a dog having paraplegia and analgesia for 3 years that was caused by a chronic spinal cord injury secondary to Hansen type I thoracolumbar disk herniation. Functional recovery was evaluated with electrophysiologic studies and the Texas Spinal Cord Injury Scale.
RESULTS: Somatosensory evoked potentials were absent before transplant but were detected after transplant. Functional improvement was noted (Texas Spinal Cord Injury Scale: before transplant, 0; after transplant, 6). No adverse events were observed.
CONCLUSIONS: Autologous bone marrow mononuclear cell transplant into the subarachnoid space may be a safe and beneficial treatment for chronic spinal cord injury in dogs.
MATERIALS AND METHODS: Autologous bone marrow mononuclear cell transplant was performed in a dog having paraplegia and analgesia for 3 years that was caused by a chronic spinal cord injury secondary to Hansen type I thoracolumbar disk herniation. Functional recovery was evaluated with electrophysiologic studies and the Texas Spinal Cord Injury Scale.
RESULTS: Somatosensory evoked potentials were absent before transplant but were detected after transplant. Functional improvement was noted (Texas Spinal Cord Injury Scale: before transplant, 0; after transplant, 6). No adverse events were observed.
CONCLUSIONS: Autologous bone marrow mononuclear cell transplant into the subarachnoid space may be a safe and beneficial treatment for chronic spinal cord injury in dogs.
Предметные рубрики MeSH
AnimalsBiopsyBone Marrow TransplantationChronic DiseaseDecompression, SurgicalDiskectomyDog DiseasesDogsEvoked Potentials, SomatosensoryIntervertebral Disc DisplacementMagnetic Resonance ImagingMotor ActivityNeurologic ExaminationRecovery of FunctionSpinal Cord InjuriesTomography, X-Ray ComputedTransplantation, AutologousTreatment Outcome