Photodiagnosis and photodynamic therapy · 2026
Effects of low-level LED red-light therapy on axial elongation in hyperopic children: A bidirectional cohort study.
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Li Ya, Zhou Chuyu, Ji Qingyun, Ding Gang, Qi Xiaoli, Li Xue, Li Jing, Qian Xuehan
Аннотация
PURPOSE: To investigate whether low-level LED red-light therapy promotes axial elongation in hyperopic children.
METHODS: This bidirectional cohort study included 201 hyperopic children aged 4 -13 years. Participants were divided into two groups: the LED group (n = 51), who received low-level LED red-light therapy, and the spectacle-only comparison group (n = 150). Axial length (AL) was measured at baseline and each follow-up. Longitudinal changes in AL were analyzed using a linear mixed-effects model (LMM). Inverse probability of treatment weighting (IPTW) was performed as a sensitivity analysis to minimize potential confounding. In a subgroup of 40 anisometropic children who received unilateral LED treatment, interocular comparisons between treated and fellow eyes were conducted using paired t-tests, and within-subject LMM analyses to assess eye-specific treatment effects.
RESULTS: The LED group showed a significantly faster rate of axial elongation than the comparison group (interaction β=+0.082 mm/year, 95% CI: 0.042 to 0.122; p < 0.001). In the anisometropic subgroup, treated eyes elongated significantly faster than fellow eyes (mean difference = +0.167 mm/year, 95% CI: 0.109-0.226; p < 0.001), leading to a reduction in interocular axial length disparity. LMM confirmed a greater time-dependent increase in treated eyes (β = +0.151 mm/year, 95% CI: 0.102-0.199; p < 0.001).
CONCLUSIONS: Low-level LED red-light therapy significantly accelerates axial elongation in hyperopic children and reduces interocular differences in anisometropic cases, suggesting that it may promote more balanced binocular refractive development.
METHODS: This bidirectional cohort study included 201 hyperopic children aged 4 -13 years. Participants were divided into two groups: the LED group (n = 51), who received low-level LED red-light therapy, and the spectacle-only comparison group (n = 150). Axial length (AL) was measured at baseline and each follow-up. Longitudinal changes in AL were analyzed using a linear mixed-effects model (LMM). Inverse probability of treatment weighting (IPTW) was performed as a sensitivity analysis to minimize potential confounding. In a subgroup of 40 anisometropic children who received unilateral LED treatment, interocular comparisons between treated and fellow eyes were conducted using paired t-tests, and within-subject LMM analyses to assess eye-specific treatment effects.
RESULTS: The LED group showed a significantly faster rate of axial elongation than the comparison group (interaction β=+0.082 mm/year, 95% CI: 0.042 to 0.122; p < 0.001). In the anisometropic subgroup, treated eyes elongated significantly faster than fellow eyes (mean difference = +0.167 mm/year, 95% CI: 0.109-0.226; p < 0.001), leading to a reduction in interocular axial length disparity. LMM confirmed a greater time-dependent increase in treated eyes (β = +0.151 mm/year, 95% CI: 0.102-0.199; p < 0.001).
CONCLUSIONS: Low-level LED red-light therapy significantly accelerates axial elongation in hyperopic children and reduces interocular differences in anisometropic cases, suggesting that it may promote more balanced binocular refractive development.