Unveiling Alpha Amylase Dynamics in Peri-Implant Crevicular Fluid: A Comparative Analysis across Peri-Implant Health and Disease Spectrums.

This study aimed to evaluate the levels of alpha amylase in patients with healthy dental implants, peri-implant mucositis, and peri-implantitis. A cross-sectional study was conducted involving 75 implant sites, divided into three groups of 25: peri-implant health, peri-implant mucositis, and peri-implantitis. Peri-implant crevicular fluid was collected from each selected implant site and analyzed for alpha amylase levels using an ELISA kit. The resulting alpha amylase concentrations were statistically compared between the groups. The mean concentration of alpha amylase was lowest in healthy sites (9.57 ± 1.59 ng/mL), compared with peri-implant mucositis (14.90 ± 2.62 ng/mL) and peri-implantitis (20.67 ± 4.55 ng/mL), with the differences being statistically significant (P = 0.00). Furthermore, multiple comparisons revealed a statistically significant distinction between the groups (P = 0.000). Elevated levels of alpha amylase in peri-implant disease sites, as opposed to healthy sites, suggest its potential as a predictive marker for peri-implant diseases.