Parkinsonism & related disorders · 2006
Spatial topography of the neurofibrillary tangles in cortical and subcortical regions in progressive supranuclear palsy.
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Armstrong Richard A, Lantos Peter L, Cairns Nigel J
Аннотация
OBJECTIVE: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP).
METHODS: Pattern analysis was carried out on tau-positive NFT in eight PSP cases.
RESULTS: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas.
CONCLUSION: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies.
METHODS: Pattern analysis was carried out on tau-positive NFT in eight PSP cases.
RESULTS: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas.
CONCLUSION: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies.